DNA synthesis inhibition, cytotoxicity and their relationship to teratogenesis following administration of a nicotinamide antagonist, aminothiadiazole, to pregnant rats.
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چکیده
منابع مشابه
The effect of aminothiadiazole on glycogenesis and glycogenolysis in fetal and neonatal rat liver.
The effect of the teratogen 2-amino-1,3,4-thiadiazole on glycogenesis and glycogenolysis was investigated in the fetal and neonatal rat liver. At day 15, 16, or 17 of gestation (sperm day = day 0) pregnant Sprague-Dawley rats received a single IP injection of an aqueous solution of aminothiadiazole. Dosages used were teratogenic (100 mg/kg maternal body weight) and nonteratogenic (10 mg/kg). At...
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Background: Nitric oxide is involved in many physiological functions of the body. And its important roles in biological process is still the matter of investigation. Nitric oxide is synthesized from the amino acid L-arginine by NO synthase in the presence of oxygen and NADHP (Nicotinamide Adenine Dinucleotide Phosphate). It has been recognized that NO has many protective roles in the immune sys...
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ورودعنوان ژورنال:
- Journal of embryology and experimental morphology
دوره 30 1 شماره
صفحات -
تاریخ انتشار 1973